Bill Watterson's Calvin and Hobbes is one my favorite comic strips, second only to Foxtrot. Wall Street Journal posted a great piece about America's funniest, strangest, and most profound comic strip.
At its simplest level, the strip is about the friendship between a bright 6-year-old misfit (Calvin) and his pet tiger (Hobbes). Its “trick” is that Hobbes is a lifeless stuffed animal when others are present and a rollicking, witty companion when they are not. So the story can be understood on many levels. It is about the richness of the imagination, the subversiveness of creativity and the irreconcilability of private yearnings and worldly reality. Where Calvin sees a leaf-monster trying to swallow him, Calvin’s father sees his troublemaker son scattering the leaf-piles he has spent all afternoon raking.